The once-daily Exelon Patch (rivastigmine transdermal system), approved by the United States Food and Drug Administration (FDA), offers a new approach to the treatment of mild to moderate Alzheimer’s disease, providing smooth and continuous delivery over 24 hours. The patch has also been approved for the treatment of mild to moderate Parkinson’s disease dementia in the U.S.
“Patches have been useful for different disease states within the medical community for some time. They allow for a smooth way to introduce medication into the body and also allow for effective and optimal dosing to be used in patients,” says Dr. Gus Alva, director of the ATP Group. “Particularly in Alzheimer’s disease, we now have a way to provide a visual reminder for the caregiver that the patient has received that day’s medication, while making the medication easier to administer than the capsule form of the medication.”
Recently-published results from a large, international, multicenter study involving nearly 1,200 patients with mild to moderate Alzheimer’s disease support the significance of this new treatment option. According to the study, the Exelon Patch has demonstrated similar efficacy to the highest doses of rivastigmine capsules (12 mg/day) with significant improvements in memory, cognition and the ability to perform everyday activities. Exelon Patch (9.5 mg/24 hours) was generally well tolerated in the clinical study-with three times fewer reports of gastrointestinal side effects (nausea and vomiting) than the oral form of the medication.
In a disease like Alzheimer’s, caregivers may have difficulty ensuring that their loved ones take their medication. In a sub-study of the clinical trial, 70 percent of caregivers preferred Exelon Patch because it helped them manage day-to-day patient care, while providing visual reassurance that the medication had been administered. The patch can be applied to the upper or lower back or upper arm or chest.
Individual experiences with the Exelon Patch may vary. For more information, visit www.ExelonPatch.com or call 1-888-NOW-NOVA (1-888-669-6682).